Abstract

Glyphosate induced renal toxicity and its amelioration with vitamin C in rats

Authors: M. Lakshmi Namratha, M. Lakshman, M. Jeevanalatha, B. Anil Kumar and Saba Rashid

DOI: http://dx.doi.org/10.71081/cvj/2022.011

Abstract
The main clinical effects of consuming glyphosate are hepatotoxicity and renal toxicity. Vitamin C, a well-known antioxidant, helps to prevent cellular damage brought on by free radicals. The aim of this study was to see how glyphosate affected renal tissues in male albino Wistar rats at a dosage of 500 mg/kg body weight (1/10 LD50) and how vitamin C responded at a dose of 250 mg/kg body weight. During these three weeks, the experimental organisms received daily oral treatments. The histology and ultrastructure pathologies of renal tissues, tissue oxidative stress parameters, and serum biochemical assays were investigated. A considerable rise in the levels of the blood enzymes urea and creatinine in the treated group was observed during this study. Malondialdehyde concentration, reduced glutathione, and superoxide dismutase levels were measured to assess oxidative stress in renal tissues. Kidney segment histopathology and ultrastructure pathology showed significant alterations. However, vitamin C treatment had a slight to moderately ameliorative effect on the examined parameters.

Keywords: Glyphosphate, Creatinine, Malondialdehyde, Free radicals, Wistar rats