Abstract

Role of Vitamin D in Recovery from Covid 19 infection

Authors: Dua e Fathah, Areeba Yousaf and Mirza Imran Shahzad

DOI: http://dx.doi.org/10.71081/cvj/2023.001

Abstract
Initially, COVID- 19 occurs in 2019 in the city of Wuhan China and began to spread. The common indications of COVID-19 are dyspnea, sore throat, cough, and fatigue. Many drugs have been used to decrease the overwhelming results such as Ivermectin, Colchicine, Metformin, and Fluvoxamine are the most affected anti-parasite. Anti-parasitic drugs also contain some side effects. Numerous dietary factors have been used but deficiency of vitamin D has been allied with an intensification in ICU treatment of patients infected with COVID-19. The central role of vitamin D in the human body is to sustain immunomodulatory, and calcium homeostasis and have anti-inflammatory, anti-fibrotic properties. Past studies show that vitamin D has a role in the reduction of respiratory diseases in adults and children. The common sources of vitamin D are meat, fish, milk products, eggs, mushrooms, sunlight, etc. Corona-viruses are enveloped by membranes, contain positive Single-Stranded RNA (+ssRNA), or can cause infection in equally animals and humans. S protein in the COVID- 19 binds to the ACE 2 receptor, leading to the virus's entry into the body. A host with a sufficient level of vitamin D has been allied with amplified excretion of anti-microbial peptides or depressing the menace of hypercytokinemia, also tangled in the stimulation of macrophages i.e., defensive cells or protected response of Th2 cells. Various studies have determined that there is no protagonist of vitamin D in managing of hazards of COVID-19. Thus, this review aims to clarify the immune-modulatory effects of vitamin D in the control of COVID-19.

Keywords: COVID- 19, Calciferol, Vitamin D, Autoimmune diseases, Metabolism